Skip to content
Two fitness woman promoting Semaglutide and Tirzepatide weight loss injections in Medford, and Grants Pass OR

Switching From Semaglutide to Tirzepatide for Weight Loss: Everything You Need to Know to Have a Smooth Transition

Semaglutide is currently one of the world’s most celebrated and well-known weight loss medications. But despite its impressive reputation for helping people from all walks of life drop pounds, it may not be the right solution for everyone. Some people may experience unwanted side effects while taking it. Others may not be able to get the results they want and may decide to try a different drug. Your provider may recommend switching from Semaglutide to Tirzepatide, depending on your situation.

Benefits of Semaglutide and Tirzepatide

Benefits of Semaglutide and Tirzepatide, a service offered at Admire Aesthetics in Medford, and Grants Pass OR

You should know a few things if you’re thinking about switching from Semaglutide to Tirzepatide. It’s important to understand how these medications work, what benefits they offer, and how they differ from each other. They both mimic the functions of glucagon-like peptide-1 receptor agonists. That’s why they are commonly referred to as GLP-1 agonists.

GLP-1 agonists treat type 2 diabetes and facilitate weight loss. They reduce caloric intake and facilitate weight loss. They also decrease blood sugar levels and stimulate increased insulin production and secretion. Finally, GLP-1 agonists slow the rate at which the stomach empties. This can help you feel hungry less frequently and full more quickly when you eat.

Here are some of the top benefits shared by both Semaglutide and Tirzepatide:

  • Reduced blood glucose levels
  • Improved insulin release
  • Weight loss
  • Reduced caloric intake
  • Appetite suppression
  • Increased satiation following meals
  • Reduced risk of heart disease, stroke, and other obesity-related problems

Switching from Semaglutide to Tirzepatide (or vice versa) isn’t as uncommon as you might think. Since the two medications offer similar benefits, trying the other one is not a big deal if the first one doesn’t work well for you. Your provider can help you know whether this is the right course of action for you to take.

What’s the Difference Between Semaglutide and Tirzepatide?

Semaglutide and Tirzepatide weight loss injections offered at Admire Aesthetics in Medford, and Grants Pass OR

Though they both work similarly to reduce appetite and weight, Semaglutide and Tirzepatide still have some notable differences. Here are a few of them.


Semaglutide and Tirzepatide are both GLP-1 agonists. However, Tirzepatide also works on the gastric inhibitory polypeptide (GIP-1) receptor. This unique function makes Tirzepatide a dual agonist, while Semaglutide is not. The gut naturally secretes the GIP hormone in response to food consumption. This hormone blocks the secretion of hydrochloric acid into the stomach. In this way, it helps slow down digestion, so it takes your body longer to feel hungry again after eating.

GIP also stimulates insulin secretion and aids in blood glucose control. Thanks to its dual functions as a GLP-1 and GIP receptor agonist, Tirzepatide can potentially deliver weight loss results superior to Semaglutide.

Related Reading: Everything You Need to Know about Compounded Tirzepatide>>


If you’re considering switching from Semaglutide to Tirzepatide, you may have questions about which medication is more effective. Both have an impressive list of benefits and equally impressive weight-loss results. However, regarding blood glucose control and lost pounds, Tirzepatide appears to have a slight advantage (as shown in clinical trials).

This is not to say Semaglutide isn’t a good weight loss medication choice for many people. Clinical trials illustrate that consistent Semaglutide injections over the course of 68 weeks yield a mean body weight change of 14.9%. So, no matter which medication you choose to take, you’ll likely lose weight while on it.


Founded in 1923, Novo Nordisk is the company that makes some of the most popular name-brand Semaglutide medications (Wegovy® and Ozempic®). This well-known pharmaceutical behemoth is based in Denmark, but it maintains offices, affiliates, and production facilities worldwide.

Eli Lilly and Co. makes Mounjaro® and Zepbound™, two of the leading Tirzepatide medications in the world. This American pharmaceutical company was founded in 1876 and has offices in 18 countries. However, its impressively large headquarters are in Indianapolis, Indiana.

FDA Approval

Before switching from Semaglutide to Tirzepatide, ensure the medication you select meets your health needs. The FDA doesn’t approve every formula containing these two ingredients for the same purposes. Specific Semaglutide formulas have FDA approval for the following:

Specific Tirzepatide formulas have FDA approval for:

  • Chronic weight management
  • Type 2 diabetes

Tirzepatide is not FDA-approved to reduce the risk of serious heart problems.


Semaglutide and Tirzepatide both require weekly doses. However, they differ in dosage amounts. When you receive Semaglutide injections, you typically start with just 0.25 mg per week. Over time, you slowly increase to a dose of up to 2.4 mg per week.

Tirzepatide injections, on the other hand, usually start with a 5 mg weekly dosage. Your provider will try to slowly increase your dosage to up to 20 mg per week.

Side Effects

Many people who consider switching from Semaglutide to Tirzepatide do so because they hope for reduced side effects. While the list of side effects is remarkably similar between the two drugs, the severity is not. Tirzepatide can cause more frequent and severe side effects because the active ingredient dosage is higher. This higher dosage often results in more rapid and pronounced weight loss results.

Here are some of the most common side effects shared by both Semaglutide and Tirzepatide injections:

  • Nausea
  • Bloating and gas
  • Diarrhea or constipation
  • Dizziness
  • Heartburn or acid reflux
  • Localized injection site reactions
  • Vomiting
  • Abdominal pain
  • Headaches

The good news is that most people experience a steady decline in symptoms after the first few weeks of treatment. So, even if you have a lot of side effects in the beginning, that doesn’t mean you’ll continue to have them throughout the duration of your treatment.

As your body grows accustomed to the medication, it may stop reacting negatively to it. Additionally, your provider can adjust your weekly dosage to help relieve some of your complaints. If you experience a lot of symptoms while on Semaglutide, your provider may recommend switching from Semaglutide to Tirzepatide and seeing if you fare better.

Rarely, patients may experience serious, potentially life-threatening complications from Semaglutide or Tirzepatide injections. These may include kidney problems, gallbladder disease, serious allergic reactions, pancreatitis, diabetic retinopathy, hypoglycemia, and an increased risk of thyroid cancer. If you experience any reactions like this, seek emergency care immediately.

Attending your regularly scheduled appointments can help reduce your likelihood of developing serious adverse effects from weight loss injections. Your provider will monitor your health closely and watch for any signs of complications throughout your treatment. If they see any warning signs, they’ll likely recommend you stop the injections immediately or drastically reduce your dosage.

Can I Switch From Semaglutide to Tirzepatide?

It’s not uncommon for patients to want to switch from Semaglutide to Tirzepatide once they learn the latter can produce more impressive weight loss. Making this switch is usually perfectly safe, but it should only be done under the direction of a skilled provider or doctor.

Remember, weekly doses differ between these two medications. Therefore, you wouldn’t want to take the same dosage when switching to the new medication. Taking a higher-than-recommended dose could result in serious side effects.

How to Boost the Effectiveness of Weight Loss Medications

Man eating healthy meal promoting Semaglutide and Tirzepatide weight loss injections available at Admire Aesthetics in Medford, and Grants Pass OR

Whether you switch from Semaglutide to Tirzepatide or not, your daily choices can significantly impact your weight loss results. Sitting around and watching television all day while stuffing your face with Cheetos won’t do your body or your health any favors. You need to make some healthy lifestyle changes to enjoy the best results from your treatment now and for the long term.

Here are some of the things many providers recommend their patients do to boost the effectiveness of their weight loss injections:

  • Eat nutritious meals and avoid sugary, greasy, nutrient-poor selections
  • Quit smoking, abusing illicit substances, and taking other unhealthy, addictive substances into your body
  • Try to keep your stress levels low whenever possible and prioritize your mental health
  • Try to exercise daily
  • Get enough sleep for your body’s needs

Related Reading: Learn How to Build the Perfect Tirzepatide Meal Plan>>

It’s always difficult when you first try to make big changes. However, they’ll eventually become habits if you consistently practice healthy lifestyles. You’ll also realize how much better you feel when treating your body and mind right.

Reignite Your Weight Loss by Switching From Semaglutide to Tirzepatide

Getting stubborn extra pounds off your body can feel like a losing battle. But sometimes, you just need a little boost. Semaglutide and Tirzepatide weight loss injections can help you see dramatic results, motivating you to keep going. At Admire Aesthetics, we can help you choose the right weight-loss medication for your body’s needs.

We’re leading providers of both Semaglutide and Tirzepatide medications. After reviewing your treatment goals, current health, and family history, we can recommend the right treatment for your situation. We can help you have a smooth transition from Semaglutide to Tirzepatide if you ever decide to switch.

Contact us today at 541-210-8806 to schedule a consultation.


Please call 541-210-8806 or fill out the form below:

  • This field is for validation purposes and should be left unchanged.

By submitting this form you agree to be contacted via phone/text/email.* Reply “Stop” to opt-out.

Tiffany DiGiuseppe​, experienced and renowned technician for aesthetics at Admire Aesthetics.

Tiffany DiGiuseppe

Admire Aesthetics was founded by Tiffany DiGiuseppe. Tiffany has been in the medical field for 22 years. The last 14 years have been devoted to a wide array of medical aesthetics. Specifically, the last 10 years in body contouring.

Admire Aesthetics, Inc. is a CoolSculpting specialty practice located in Medford, OR. We are recognized by Allergan to be a Certified CoolSculpting facility, with the highest level of recognition given. We have performed over 12,000 CoolSculpting procedures! We take pride in always maintaining the most up-to-date treatment options and equipment to ensure the best results which are all backed by our “Admire Promise” guarantee.


Please call 541-210-8806 or fill out the form below:

  • This field is for validation purposes and should be left unchanged.

By submitting this form you agree to be contacted via phone/text/email.* Reply “Stop” to opt-out.

Accessibility Toolbar